For research use only. Not for therapeutic Use.
BMS309403 (Cat No.:I004461) is a small molecule inhibitor of FABP4 with a Kd value of 4 nM, and its selectivity for FABP4 is more than 100 times higher than that for FABP5 and FABP3. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.
| Catalog Number | I004461 |
| CAS Number | 300657-03-8 |
| Synonyms | BMS-309403; BMS309403; BMS 309403.;((2/’-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-1,1/’-biphenyl-3-yl)oxy)acetic acid |
| Molecular Formula | C31H26N2O3 |
| Purity | ≥95% |
| Target | FABP |
| Solubility | Soluble in DMSO, not in water |
| Storage | Room Temperature |
| IUPAC Name | 2-[3-[2-(5-ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid |
| InChI | InChI=1S/C31H26N2O3/c1-2-27-30(22-12-5-3-6-13-22)31(23-14-7-4-8-15-23)32-33(27)28-19-10-9-18-26(28)24-16-11-17-25(20-24)36-21-29(34)35/h3-20H,2,21H2,1H3,(H,34,35) |
| InChIKey | SJRVJRYZAQYCEE-UHFFFAOYSA-N |
| SMILES | CCC1=C(C(=NN1C2=CC=CC=C2C3=CC(=CC=C3)OCC(=O)O)C4=CC=CC=C4)C5=CC=CC=C5 |
| Reference | </br>1:Vasculo-protective effect of BMS-309403 is independent of its specific inhibition of fatty acid-binding protein 4. Okamura Y, Otani K, Sekiguchi A, Kogane T, Kakuda C, Sakamoto Y, Kodama T, Okada M, Yamawaki H.Pflugers Arch. 2017 Apr 13. doi: 10.1007/s00424-017-1976-0. [Epub ahead of print] PMID: 28405802 </br>2:Synthesis of BMS-309403-related compounds, including [¹⁴C]BMS-309403, a radioligand for adipocyte fatty acid binding protein. Okada T, Hiromura M, Otsuka M, Enomoto S, Miyachi H.Chem Pharm Bull (Tokyo). 2012;60(1):164-8. PMID: 22223390 Free Article</br>3:Effect of fill weight, capsule shell, and sinker design on the dissolution behavior of capsule formulations of a weak acid drug candidate BMS-309403. Wu Y, Zhao F, Paborji M.Pharm Dev Technol. 2003;8(4):379-83. PMID: 14601962 |
