BMS-345541

• CAT Number: I004019
• CAS Number: 547757-23-3
• Molecular Formula: C14H18ClN5
• Molecular Weight: 291.78
• Purity: ≥95%
• Synonyms: N/’-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine;hydrochloride
• Target: IKK
• Solubility: DMSO:18 mg/mL
• Storage: Store at -20°C
• IC50: 0.3/4 uM(IKK2/1)
• IUPAC Name: N'-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine;hydrochloride
• InChI: InChI=1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18);1H
• InChIKey: MIDKPVLYXNLFGZ-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN.Cl

BMS-345541（Cat No.:I004019）is a selective small molecule inhibitor of the IκB kinase (IKK) complex, specifically targeting IKK-β. It is primarily studied for its anti-inflammatory and anti-cancer properties due to its ability to block the nuclear factor-kappa B (NF-κB) signaling pathway. NF-κB is involved in regulating immune responses, inflammation, and cell survival, making BMS-345541 a potential therapeutic agent for inflammatory diseases and cancers where NF-κB is overactive. Preclinical studies have shown its effectiveness in reducing inflammation and inhibiting tumor growth. However, further research is required to evaluate its clinical safety and efficacy.