BMS-5

• CAT Number: I001289
• CAS Number: 1338247-35-0
• Molecular Formula: C17H14Cl2F2N4OS
• Molecular Weight: 431.30
• Purity: ≥95%
• Synonyms: LIM Kinase Inhibitor I;LIMKi 3
• Target: LIM Kinase (LIMK)
• Solubility: DMSO: ＞ 34 mg/mL
• Storage: -20°C
• IUPAC Name: N-[5-[2-(2,6-dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]-2-methylpropanamide
• InChI: InChI=1S/C17H14Cl2F2N4OS/c1-8(2)16(26)23-17-22-7-13(27-17)12-6-11(15(20)21)24-25(12)14-9(18)4-3-5-10(14)19/h3-8,15H,1-2H3,(H,22,23,26)
• InChIKey: IVUGBSGLHRJSSP-UHFFFAOYSA-N
• SMILES: CC(C)C(=O)NC1=NC=C(S1)C2=CC(=NN2C3=C(C=CC=C3Cl)Cl)C(F)F

BMS-5（Cat No.:I001289）is a selective inhibitor of bone morphogenetic protein receptor type I (BMPR-I), a key component of the BMP signaling pathway, which is involved in regulating cell growth, differentiation, and development. By inhibiting BMPR-I, BMS-5 disrupts the BMP signaling cascade, which has implications in various biological processes, including bone formation and cancer progression. This compound is used in research to study BMP-related pathways, with particular interest in skeletal disorders, fibrosis, and cancer. BMS-5’s ability to modulate these pathways makes it a valuable tool for therapeutic research and drug discovery.

Reference

[1]. Sparrow N1, Manetti ME et al。The Actin-Severing Protein Cofilin Is Downstream of Neuregulin Signaling and Is Essential For Schwann Cell Myelination. J Neurosci. 2012 Apr 11; 32(15): 5284–5297.

[2]. Alejandra Petrilli, Alicja Copik et al。LIM Domain Kinases as Potential Therapeutic Targets for Neurofibromatosis Type 2.Oncogene. 2014 Jul 3; 33(27): 3571–3582..

[3]. Weiwei Wang and Ellen Townes-Andersonl。LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury.Invest Ophthalmol Vis Sci. 2015 Dec; 56(13): 7847–7858.