BMS-502

• CAT Number: I040939
• CAS Number: 2407854-18-4
• Molecular Formula: C27H22F2N6O3
• Molecular Weight: 516.50
• Purity: ≥95%
• Synonyms: 8-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-5-methyl-7-nitro-6-oxo-1,5-naphthyridine-2-carbonitrile
• InChI: InChI=1S/C27H22F2N6O3/c1-32-22-11-10-21(16-30)31-23(22)25(26(27(32)36)35(37)38)34-14-12-33(13-15-34)24(17-2-6-19(28)7-3-17)18-4-8-20(29)9-5-18/h2-11,24H,12-15H2,1H3
• InChIKey: XAHMIJCNFUSTMT-UHFFFAOYSA-N
• SMILES: CN1C2=C(C(=C(C1=O)[N+](=O)[O-])N3CCN(CC3)C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)N=C(C=C2)C#N

BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research[1].
BMS-502 has an EC50 value of 340 nM in the mouse cytotoxic T cell IFN-γ assay (mCTC) [1].
BMS-502 (Compound 22) (0-10mg/kg; PO; 24h) demonstrates dose-dependent immune stimulation in the mouse OT-1 model[1].
Pharmacokinetic Analysis in C57 black mice Model[1]

Route
Dose (mg/kg)
AUClast (μM•h)
t1/2 (h)
Tmax (h)
Cmax (μM)
Cl (m/min/kg)
Vss (mL/kg)
F (%)

i.v.
1
14.8
22.5
/
/
1.9
3.9
/

p.o.
5
48
/
3.0
1.08
/
/
65

Reference

[1]. Chupak L, et al. Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization. ACS Med Chem Lett. 2023 Jun 12;14(7):929-935.
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