For research use only. Not for therapeutic Use.
BMS-502 (CAT: I040939) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ, with IC50 values of 4.6 nM and 2.1 nM, respectively. By inhibiting these enzymes, BMS-502 enhances T cell activation and immune responses, particularly in mouse models. This compound shows potential for boosting anti-tumor immunity by modulating T cell functions and can be leveraged in tumor immunity-related research. BMS-502 is particularly relevant for Cancer Disease Research, offering a novel approach to immunotherapy by targeting key regulators of immune cell signaling pathways.
| CAS Number | 2407854-18-4 |
| Synonyms | 8-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-5-methyl-7-nitro-6-oxo-1,5-naphthyridine-2-carbonitrile |
| Molecular Formula | C27H22F2N6O3 |
| Purity | ≥95% |
| IUPAC Name | 8-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-5-methyl-7-nitro-6-oxo-1,5-naphthyridine-2-carbonitrile |
| InChI | InChI=1S/C27H22F2N6O3/c1-32-22-11-10-21(16-30)31-23(22)25(26(27(32)36)35(37)38)34-14-12-33(13-15-34)24(17-2-6-19(28)7-3-17)18-4-8-20(29)9-5-18/h2-11,24H,12-15H2,1H3 |
| InChIKey | XAHMIJCNFUSTMT-UHFFFAOYSA-N |
| SMILES | CN1C2=C(C(=C(C1=O)[N+](=O)[O-])N3CCN(CC3)C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)N=C(C=C2)C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
