BMS-564929

• CAT Number: I004364
• CAS Number: 627530-84-1
• Molecular Formula: C14H12ClN3O3
• Molecular Weight: 305.72
• Purity: ≥95%
• Synonyms: 4-[(7R,7aS)-7-hydroxy-1,3-dioxo-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-2-chloro-3-methylbenzonitrile
• Target: Androgen Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 2.11 ± 0.16 nM (Ki value)[1]
• InChI: 1S/C14H12ClN3O3/c1-7-9(3-2-8(6-16)11(7)15)18-13(20)12-10(19)4-5-17(12)14(18)21/h2-3,10,12,19H,4-5H2,1H3/t10-,12+/m1/s1
• InChIKey: KEJORAMIZFOODM-PWSUYJOCSA-N
• SMILES: CC1=C(C=CC(=C1Cl)C#N)N2C(=O)[C@@H]3[C@@H](CCN3C2=O)O

BMS-564929 (Cat No.: I004364) is a potent, selective non-steroidal androgen receptor modulator (SARM) developed to enhance muscle and bone strength without the side effects of traditional androgens. It exhibits strong anabolic activity in skeletal muscle while minimizing activity in the prostate and other androgen-sensitive tissues. BMS-564929 has been explored for treating conditions like muscle wasting, hypogonadism, and age-related sarcopenia. Its oral bioavailability and tissue selectivity make it a promising therapeutic candidate for improving physical function and quality of life in aging and disease.

Reference

[1]. Ostrowski J, Kuhns JE, Lupisella JA, Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats. Endocrinology. 2007 Jan;148(1):4-12.
[2]. Thevis M, Kohler M, Thomas A, Determination of benzimidazole- and bicyclic hydantoin-derived selective androgen receptor antagonists and agonists in human urine using LC-MS/MS. Anal Bioanal Chem. 2008 May;391(1):251-61.