For research use only. Not for therapeutic Use.
BMS-566394 (Cat.No:I023528) is a potent, exceptionally selective inhibitor of TNF-α converting enzyme (TACE).
| Catalog Number | I023528 |
| CAS Number | 503166-51-6 |
| Synonyms | BMS566394; BMS 566394; BMS-566394 |
| Molecular Formula | C22H21F3N4O4 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (3R,4R)-N-Hydroxy-4-[[4-[[2-(trifluoromethyl)benzimidazol-1-yl]methyl]benzoyl]amino]oxane-3-carboxamide |
| InChI | InChI=1S/C22H21F3N4O4/c23-22(24,25)21-27-17-3-1-2-4-18(17)29(21)11-13-5-7-14(8-6-13)19(30)26-16-9-10-33-12-15(16)20(31)28-32/h1-8,15-16,32H,9-12H2,(H,26,30)(H,28,31)/t15-,16+/m0/s1 |
| InChIKey | PGVYYPZKXKGBLD-JKSUJKDBSA-N |
| SMILES | O=C([C@H]1COCC[C@H]1NC(C2=CC=C(CN3C4=CC=CC=C4N=C3C(F)(F)F)C=C2)=O)NO |
| Reference | 1: Romee R, Foley B, Lenvik T, Wang Y, Zhang B, Ankarlo D, Luo X, Cooley S, Verneris M, Walcheck B, Miller J. NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17). Blood. 2013 May 2;121(18):3599-608. doi: 10.1182/blood-2012-04-425397. Epub 2013 Mar 13. PMID: 23487023; PMCID: PMC3643761. |
