BMS-582949

• CAT Number: M019910
• CAS Number: 623152-17-0
• Molecular Formula: C22H26N6O2
• Molecular Weight: 406.48
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CCCNC(=O)C1=CN2C(=C1C)C(=NC=N2)NC3=C(C=CC(=C3)C(=O)NC4CC4)C

BMS-582949 (PS540446) is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM,inhibiting both p38 kinase activity and activation of p38.

Reference

[1] Liu C, et al. J Med Chem. 2010, 53(18):6629-6639.
[2] Schieven, et al. Arthritis Rheum. 2010, 62 Suppl 10:1513. [abstract]