For research use only. Not for therapeutic Use.
BMS-833923 (Cat.No:I000303) is a potent and selective inhibitor of transforming growth factor-beta receptor type I (TGF-βRI) kinase. It has shown antitumor activity in preclinical models of various cancer types, including breast, prostate, and lung cancer. BMS-833923 has also demonstrated potential as a treatment for fibrotic diseases such as pulmonary fibrosis and liver fibrosis. Clinical trials evaluating its safety and efficacy are ongoing.
| Catalog Number | I000303 |
| CAS Number | 1059734-66-5 |
| Synonyms | N-[2-methyl-5-(methylaminomethyl)phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide |
| Molecular Formula | C₃₀H₂₇N₅O |
| Purity | ≥95% |
| Target | Smoothened |
| Solubility | in DMSO > 10 mM |
| Storage | Store at -20°C |
| IC50 | 6-35 nM |
| IUPAC Name | N-[2-methyl-5-(methylaminomethyl)phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide |
| InChI | InChI=1S/C30H27N5O/c1-20-12-13-21(19-31-2)18-27(20)33-29(36)23-14-16-24(17-15-23)32-30-34-26-11-7-6-10-25(26)28(35-30)22-8-4-3-5-9-22/h3-18,31H,19H2,1-2H3,(H,33,36)(H,32,34,35) |
| InChIKey | KLRRGBHZCJLIEL-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)CNC)NC(=O)C2=CC=C(C=C2)NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5 |
