BMS-919373

• CAT Number: I004695
• CAS Number: 1272353-82-8
• Molecular Formula: C25H20N6O2S
• Molecular Weight: 468.53
• Purity: ≥95%
• Synonyms: 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide
• InChI: InChI=1S/C25H20N6O2S/c26-34(32,33)20-13-18(14-27-16-20)24-30-22-11-6-10-21(17-7-2-1-3-8-17)23(22)25(31-24)29-15-19-9-4-5-12-28-19/h1-14,16H,15H2,(H2,26,32,33)(H,29,30,31)
• InChIKey: XGKULQQVQWCASY-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=C3C(=CC=C2)N=C(N=C3NCC4=CC=CC=N4)C5=CC(=CN=C5)S(=O)(=O)N

BMS-919373(CAT: I004695) is a selective small-molecule activator of the cardiac myosin protein, primarily studied for its potential in treating heart failure. It works by enhancing cardiac contractility through increasing the force of contraction in heart muscle cells without significantly increasing energy expenditure or oxygen demand. This mechanism is particularly beneficial in conditions where the heart’s pumping efficiency is compromised, such as in systolic heart failure. BMS-919373 has been explored in preclinical and clinical settings to assess its therapeutic value in improving cardiac function, with the goal of providing a novel treatment option for patients with heart failure.