For research use only. Not for therapeutic Use.
BMS-963272 is a potent, selective MGAT2 inhibitor (IC50 = 7.1 nM) for the research of metabolic disorders.
| Catalog Number | I045331 |
| CAS Number | 1441057-15-3 |
| Synonyms | (2S)-4-(4-methylphenyl)-5-(2H-tetrazol-5-yl)-2-[4-(4,4,4-trifluorobutoxy)phenyl]-2-(trifluoromethyl)-1,3-dihydropyridin-6-one |
| Molecular Formula | C24H21F6N5O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H21F6N5O2/c1-14-3-5-15(6-4-14)18-13-22(24(28,29)30,31-21(36)19(18)20-32-34-35-33-20)16-7-9-17(10-8-16)37-12-2-11-23(25,26)27/h3-10H,2,11-13H2,1H3,(H,31,36)(H,32,33,34,35)/t22-/m0/s1 |
| InChIKey | AEMPUAWUDAMJBV-QFIPXVFZSA-N |
| SMILES | CC1=CC=C(C=C1)C2=C(C(=O)NC(C2)(C3=CC=C(C=C3)OCCCC(F)(F)F)C(F)(F)F)C4=NNN=N4 |
| Reference | [1]. Turdi H, et al. Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders. J Med Chem. 2021 Oct 14;64(19):14773-14792. |
