BMS-986115

• CAT Number: I004715
• CAS Number: 1584647-27-7
• Molecular Formula: C26H23F3N4O5
• Molecular Weight: (2S,3R)-N'-[(3S)-5-(3-fluorophenyl)-9-methyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide
• Purity: ≥95%
• Synonyms: BMS-986115; BMS 986115; BMS986115.
• Target: gamma secretase inhibitor
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term or -20 °C for long term
• IUPAC Name: InChI=1S/C26H25F7N4O3/c1-13-4-2-7-18-19(13)36-24(40)22(35-20(18)14-5-3-6-15(27)12-14)37-23(39)17(9-11-26(31,32)33)16(21(34)38)8-10-25(28,29)30/h2-7,12,16-17,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,22+/m0/s1
• InChI: SRJNRAQUSAVENA-GSHUGGBRSA-N
• InChIKey: CC1=C2C(=CC=C1)C(=N[C@@H](C(=O)N2)NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(=O)N)C3=CC(=CC=C3)F
• SMILES: Unknown

BMS-986115(CAT: I004715) is an orally bioavailable gamma secretase (GS) and pan-Notch inhibitor with potential antineoplastic activity. It functions by binding to gamma secretase, thereby blocking the proteolytic cleavage of Notch receptors, which prevents the release of the Notch intracellular domain (NICD). This inhibition disrupts Notch signaling, a pathway often overactivated in various cancers, and impairs tumor cell proliferation, survival, and differentiation. BMS-986115 is a valuable tool in oncology research, particularly for studying Notch-dependent tumorigenesis and exploring therapeutic strategies targeting Notch signaling in hematologic malignancies and solid tumors.