For research use only. Not for therapeutic Use.
BMS-986115 (Notch inhibitor 1) is a potent Notch inhibitor, with IC50s of 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively. Used in the research of cancer[1].
BMS-986115 (Example 1) potently inhibits Notch signaling pathway[1].
| CAS Number | 1584647-27-7 |
| Synonyms | (2S,3R)-N’-[(3S)-5-(3-fluorophenyl)-9-methyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide |
| Molecular Formula | C26H25F7N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H25F7N4O3/c1-13-4-2-7-18-19(13)36-24(40)22(35-20(18)14-5-3-6-15(27)12-14)37-23(39)17(9-11-26(31,32)33)16(21(34)38)8-10-25(28,29)30/h2-7,12,16-17,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,22+/m0/s1 |
| InChIKey | SRJNRAQUSAVENA-GSHUGGBRSA-N |
| SMILES | CC1=C2C(=CC=C1)C(=NC(C(=O)N2)NC(=O)C(CCC(F)(F)F)C(CCC(F)(F)F)C(=O)N)C3=CC(=CC=C3)F |
| Reference | [1]. Ashvinikumar V. Gavai, et al. Bis(fluoroalkyl)-1,4-benzodiazepinone compounds as notch inhibitors. WO2014047372A1. |
