BMS-986235

• CAT Number: I015143
• CAS Number: 2253947-47-4
• Molecular Formula: C₁₈H₁₇F₂N₃O₃
• Molecular Weight: 361.34
• Purity: ≥95%
• IUPAC Name: 1-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-phenylurea
• InChI: InChI=1S/C18H17F2N3O3/c1-26-11-7-13(19)15(14(20)8-11)12-9-21-17(24)16(12)23-18(25)22-10-5-3-2-4-6-10/h2-8,12,16H,9H2,1H3,(H,21,24)(H2,22,23,25)/t12-,16-/m0/s1
• InChIKey: FJZNNKJZHQFMCK-LRDDRELGSA-N
• SMILES: COC1=CC(=C(C(=C1)F)C2CNC(=O)C2NC(=O)NC3=CC=CC=C3)F

BMS-986235（Cat No.:I015143）, also known as LAR-1219, is a selective and orally active agonist of formyl peptide receptor 2 (FPR2). It demonstrates high affinity for FPR2 with EC50 values of 0.41 nM and 3.4 nM for human (hFPR2) and mouse (mFPR2) receptors, respectively. This compound holds promise for the prevention of heart failure. By targeting FPR2, BMS-986235 may modulate signaling pathways involved in inflammation, immune response, and cardiovascular function, potentially offering therapeutic benefits in the management and prevention of heart failure.

Reference

[1]. Asahina Y, et al. Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure [published online ahead of print, 2020 May 24]. J Med Chem. 2020;10.1021/acs.jmedchem.9b02101.