For research use only. Not for therapeutic Use.
BMS202 hydrochloride is a PD-1/PD-L1 interaction inhibitor with an IC50 value of 18 nM. KEYWORDS: BMS202 hydrochloride | Supplier | PD-1/PD-L1 inhibitor | PCC0208025 | BMS 202 | BMS-202 | PCC 0208025 | PCC-0208025 | CAS [1675203-84-5] | CAS [2089334-95-0] | T-Cell activity | PD-1 | Inhibitor | Proteins | Melanoma | Programmed cell death-1 | Programmed death-ligand 1
Catalog Number | I047741 |
CAS Number | 2089334-95-0 |
Molecular Formula | C25H29N3O3·HCl |
Purity | ≥95% |
IUPAC Name | N-[2-[[2-methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl]methylamino]ethyl]acetamide;hydrochloride |
InChI | InChI=1S/C25H29N3O3.ClH/c1-18-22(10-7-11-23(18)20-8-5-4-6-9-20)17-31-24-13-12-21(25(28-24)30-3)16-26-14-15-27-19(2)29;/h4-13,26H,14-17H2,1-3H3,(H,27,29);1H |
SMILES | CC1=C(C=CC=C1C2=CC=CC=C2)COC3=NC(=C(C=C3)CNCCNC(=O)C)OC.Cl |
Reference | K Guzik et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867.Z Hu et al. PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice. PLoS One. 2020 Mar 26;15(3):e0228339. |