BMS202 hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I047741
  • CAS Number: 2089334-95-0
  • Molecular Formula: C25H29N3O3·HCl
  • Molecular Weight: 455.98
  • Purity: ≥95%
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BMS202 hydrochloride is a PD-1/PD-L1 interaction inhibitor with an IC50 value of 18 nM. KEYWORDS: BMS202 hydrochloride | Supplier | PD-1/PD-L1 inhibitor | PCC0208025 | BMS 202 | BMS-202 | PCC 0208025 | PCC-0208025 | CAS [1675203-84-5] | CAS [2089334-95-0] | T-Cell activity | PD-1 | Inhibitor | Proteins | Melanoma | Programmed cell death-1 | Programmed death-ligand 1


Catalog Number I047741
CAS Number 2089334-95-0
Molecular Formula C25H29N3O3·HCl
Purity ≥95%
IUPAC Name N-[2-[[2-methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl]methylamino]ethyl]acetamide;hydrochloride
InChI InChI=1S/C25H29N3O3.ClH/c1-18-22(10-7-11-23(18)20-8-5-4-6-9-20)17-31-24-13-12-21(25(28-24)30-3)16-26-14-15-27-19(2)29;/h4-13,26H,14-17H2,1-3H3,(H,27,29);1H
SMILES CC1=C(C=CC=C1C2=CC=CC=C2)COC3=NC(=C(C=C3)CNCCNC(=O)C)OC.Cl
Reference

K Guzik et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867.Z Hu et al. PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice. PLoS One. 2020 Mar 26;15(3):e0228339.

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