For research use only. Not for therapeutic Use.
BMS270394 (Cat.No:I004445) is a potent and selective inhibitor of P38 MAP kinase, which plays a crucial role in inflammation and stress response. In vitro studies have shown that BMS270394 inhibits the activity of P38 MAP kinase with an IC50 of 10nM. It also exhibits excellent selectivity against other kinases, including JNK, ERK2, and GSK3β. BMS270394 has potential therapeutic applications in the treatment of inflammatory and autoimmune diseases.
| Catalog Number | I004445 |
| CAS Number | 262433-54-5 |
| Synonyms | BMS270394; BMS-270394 ; BMS 270394; BMS 189961.;3-fluoro-4-[[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)acetyl]amino]benzoic acid |
| Molecular Formula | C23H26FNO4 |
| Purity | ≥95% |
| Target | RAR-γ agonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term or -20 °C for long term |
| IUPAC Name | 3-fluoro-4-[[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)acetyl]amino]benzoic acid |
| InChI | InChI=1S/C23H26FNO4/c1-22(2)9-10-23(3,4)16-11-13(5-7-15(16)22)19(26)20(27)25-18-8-6-14(21(28)29)12-17(18)24/h5-8,11-12,19,26H,9-10H2,1-4H3,(H,25,27)(H,28,29)/t19-/m1/s1 |
| InChIKey | AANFHDFOMFRLLR-LJQANCHMSA-N |
| SMILES | O=C(O)C1=CC=C(NC([C@H](O)C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)=O)C(F)=C1 |
| Reference | </br>1: Klaholz BP, Mitschler A, Belema M, Zusi C, Moras D. Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6322-7. PubMed PMID: 10841540; Pu |
