For research use only. Not for therapeutic Use.
BMS641 is a RARβ-selective agonist. BMS641 is a potential tumor suppressor.
| Catalog Number | I004614 |
| CAS Number | 369364-50-1 |
| Synonyms | BMS641; BMS-641; BMS 641.;3-chloro-4-[(E)-2-(5,5-dimethyl-8-phenyl-6H-naphthalen-2-yl)ethenyl]benzoic acid |
| Molecular Formula | C27H23ClO2 |
| Purity | ≥95% |
| Target | Vitamin D Related/Nuclear Receptor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term or -20 °C for long term |
| InChI | InChI=1S/C27H23ClO2/c1-27(2)15-14-22(19-6-4-3-5-7-19)23-16-18(9-13-24(23)27)8-10-20-11-12-21(26(29)30)17-25(20)28/h3-14,16-17H,15H2,1-2H3,(H,29,30)/b10-8+ |
| InChIKey | FRTYVAKGTFXRNY-CSKARUKUSA-N |
| SMILES | O=C(O)C1=CC=C(/C=C/C2=CC=C3C(C)(C)CC=C(C4=CC=CC=C4)C3=C2)C(Cl)=C1 |
| Reference | </br>1: Nadendla E, Teyssier C, Delfosse V, Vivat V, Krishnasamy G, Gronemeyer H, Bourguet W, Germain P. An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist. PLoS One. 2015 May 1;10(5):e0123195. |
