For research use only. Not for therapeutic Use.
BMS905(CAT: I040932) is an orally active dual inhibitor of Toll-like receptors 7 (TLR7) and 8 (TLR8), with IC50 values of 0.7 nM and 3.2 nM, respectively. By inhibiting TLR7 and TLR8, BMS905 effectively reduces interleukin-6 (IL-6) production induced by these receptors in both human and mouse whole blood. Given its ability to modulate immune responses, BMS905 shows potential in the treatment of autoimmune diseases like lupus, where excessive TLR7/8 activation contributes to disease pathogenesis. This compound is highly relevant for Inflammation & Immunology Research, offering a promising therapeutic strategy for lupus and other related autoimmune disorders.
| CAS Number | 2205846-49-5 |
| Synonyms | 2-(2,6-dimethylpyridin-4-yl)-5-piperidin-4-yl-3-propan-2-yl-1H-indole |
| Molecular Formula | C23H29N3 |
| Purity | ≥95% |
| IUPAC Name | 2-(2,6-dimethylpyridin-4-yl)-5-piperidin-4-yl-3-propan-2-yl-1H-indole |
| InChI | InChI=1S/C23H29N3/c1-14(2)22-20-13-18(17-7-9-24-10-8-17)5-6-21(20)26-23(22)19-11-15(3)25-16(4)12-19/h5-6,11-14,17,24,26H,7-10H2,1-4H3 |
| InChIKey | XSXCQWXAFRASGU-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC(=N1)C)C2=C(C3=C(N2)C=CC(=C3)C4CCNCC4)C(C)C |
