For research use only. Not for therapeutic Use.
BMS905 is an orally active TLR7 and TLR8 dual inhibitor (IC50s: 0.7 and 3.2 nM respectively). BMS905 inhibits TLR7 or TLR8 induced IL-6 production in human/mouse whole blood. BMS905 can be used for research of lupus[1].
| Catalog Number | I040932 |
| CAS Number | 2205846-49-5 |
| Synonyms | 2-(2,6-dimethylpyridin-4-yl)-5-piperidin-4-yl-3-propan-2-yl-1H-indole |
| Molecular Formula | C23H29N3 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H29N3/c1-14(2)22-20-13-18(17-7-9-24-10-8-17)5-6-21(20)26-23(22)19-11-15(3)25-16(4)12-19/h5-6,11-14,17,24,26H,7-10H2,1-4H3 |
| InChIKey | XSXCQWXAFRASGU-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC(=N1)C)C2=C(C3=C(N2)C=CC(=C3)C4CCNCC4)C(C)C |
| Reference | [1]. Sreekantha RK, et al. Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8). ACS Med Chem Lett. 2022 Apr 25;13(5):812-818. |
