For research use only. Not for therapeutic Use.
BN80933 is a dual inhibitor of lipid peroxidation (IC50 value of 0.29 μM) and neuronal nitric oxide synthase (nNOS) (Ki value of 0.92 μM); Neuroprotectant.
KEYWORDS: BN80933 | Supplier | Antioxidant/nNOS inhibitor | BN 80933 | BN-80933 | CAS [214348-10-4] | [214123-99-6] | [262862-31-7] | L-Arginine | NOS | Inhibitor | Enzymes | Nitric oxide | NO | Reactive oxygen species | ROS | Neuroprotective | Stroke | Trauma
| Catalog Number | I047671 |
| CAS Number | 214348-10-4 |
| Molecular Formula | C29H34N4O3S |
| Purity | ≥95% |
| IUPAC Name | N'-[4-[4-[(2S)-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carbonyl]piperazin-1-yl]phenyl]thiophene-2-carboximidamide |
| InChI | InChI=1S/C29H34N4O3S/c1-18-19(2)26-23(20(3)25(18)34)11-12-29(4,36-26)28(35)33-15-13-32(14-16-33)22-9-7-21(8-10-22)31-27(30)24-6-5-17-37-24/h5-10,17,34H,11-16H2,1-4H3,(H2,30,31)/t29-/m0/s1 |
| SMILES | CC1=C(C2=C(CC[C@@](O2)(C)C(=O)N3CCN(CC3)C4=CC=C(C=C4)N=C(C5=CC=CS5)N)C(=C1O)C)C |
| Reference | PE Chabrier et al. BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: a promising neuroprotective strategy. Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10824-9. |
