Bobcat339 free base

• CAT Number: I023598
• CAS Number: 2280037-51-4
• Molecular Formula: C16H12ClN3O
• Molecular Weight: 297.74
• Purity: 98%
• Synonyms: Bobcat339; Bobcat-339; Bobcat 339; Bobcat339 free base
• Target: DNA Methyltransferase
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4-amino-5-chloro-1-(3-phenylphenyl)pyrimidin-2-one
• InChI: InChI=1S/C16H12ClN3O/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,18,19,21)
• InChIKey: QMGYGOOYCNTEQO-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=CC(=CC=C2)N3C=C(C(=NC3=O)N)Cl

Bobcat339(CAT: I023598) is a novel cytosine-based inhibitor of TET enzymes, with IC₅₀ values of 33 μM for TET1 and 73 μM for TET2, demonstrating mid-μM inhibitory activity. Unlike many epigenetic modulators, it selectively targets TET enzymes without affecting DNA methyltransferases such as DNMT3a. This specificity makes Bobcat339 a valuable tool in epigenetics research, enabling the study of TET-mediated DNA demethylation and its role in regulating gene transcription. Its mechanism offers insights into the modulation of DNA methylation dynamics and serves as a foundation for developing novel therapeutics for diseases associated with epigenetic dysregulation, including cancer and neurological disorders.