For research use only. Not for therapeutic Use.
Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2). Bobcat339 has mid-μM inhibitor activity against TET1 and TET2, but does not inhibit the DNA methyltransferase, DNMT3a. These new molecular tools will be useful to the field of epigenetics and serve as a starting point for new therapeutics that target DNA methylation and gene transcription.
| Catalog Number | I023598 |
| CAS Number | 2280037-51-4 |
| Synonyms | Bobcat339; Bobcat-339; Bobcat 339; Bobcat339 free base |
| Molecular Formula | C16H12ClN3O |
| Purity | 98% |
| Target | DNA Methyltransferase |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one |
| InChI | InChI=1S/C16H12ClN3O/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,18,19,21) |
| InChIKey | QMGYGOOYCNTEQO-UHFFFAOYSA-N |
| SMILES | O=C1N=C(N)C(Cl)=CN1C2=CC(C3=CC=CC=C3)=CC=C2 |
| Reference | 1: Chua GNL, Wassarman KL, Sun H, Alp JA, Jarczyk EI, Kuzio NJ, Bennett MJ, Malachowsky BG, Kruse M, Kennedy AJ. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31;10(2):180-185. doi: 10.1021/acsmedchemlett.8b00474.eCollection 2019 Feb 14. PubMed PMID: 30783500; PubMed Central PMCID: PMC6378777. |
