Bobcat339 hydrochloride

• CAT Number: I019412
• CAS Number: 2436747-44-1
• Molecular Formula: C16H13Cl2N3O
• Molecular Weight: 334.20
• Purity: ≥95%
• Synonyms: 4-amino-5-chloro-1-(3-phenylphenyl)pyrimidin-2-one;hydrochloride
• InChI: InChI=1S/C16H12ClN3O.ClH/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11;/h1-10H,(H2,18,19,21);1H
• InChIKey: ZOMPKMMOPYMRIB-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=CC(=CC=C2)N3C=C(C(=NC3=O)N)Cl.Cl

Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].
Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells[1].

Reference

[1]. Chua GNL, et al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31;10(2):180-185.
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