For research use only. Not for therapeutic Use.
Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | R055572 |
| CAS Number | 6404-29-1 |
| Synonyms | 6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid |
| Molecular Formula | C11H21NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H21NO4/c1-11(2,3)16-10(15)12-8-6-4-5-7-9(13)14/h4-8H2,1-3H3,(H,12,15)(H,13,14) |
| InChIKey | RUFDYIJGNPVTAY-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NCCCCCC(=O)O |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
