Boc-aminooxy-amide-PEG4-propargyl

• CAT Number: I016249
• CAS Number: 2253965-01-2
• Molecular Formula: C18H32N2O8
• Molecular Weight: 404.46
• Purity: ≥95%
• Synonyms: tert-butyl N-[2-oxo-2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethylamino]ethoxy]carbamate
• InChI: InChI=1S/C18H32N2O8/c1-5-7-23-9-11-25-13-14-26-12-10-24-8-6-19-16(21)15-27-20-17(22)28-18(2,3)4/h1H,6-15H2,2-4H3,(H,19,21)(H,20,22)
• InChIKey: XDRDVAXJEVQKKC-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NOCC(=O)NCCOCCOCCOCCOCC#C

Boc-aminooxy-amide-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Boc-aminooxy-amide-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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