For research use only. Not for therapeutic Use.
Boc-Aminooxy-PEG2-C2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Catalog Number | I014705 |
CAS Number | 252378-69-1 |
Synonyms | tert-butyl N-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]carbamate |
Molecular Formula | C11H24N2O5 |
Purity | ≥95% |
InChI | InChI=1S/C11H24N2O5/c1-11(2,3)18-10(14)13-17-9-8-16-7-6-15-5-4-12/h4-9,12H2,1-3H3,(H,13,14) |
InChIKey | LHNRKSSHYXYKTA-UHFFFAOYSA-N |
SMILES | CC(C)(C)OC(=O)NOCCOCCOCCN |
Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |