For research use only. Not for therapeutic Use.
Boc-Aminooxy-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I014704 |
| CAS Number | 1807503-86-1 |
| Synonyms | tert-butyl N-[2-(2-hydroxyethoxy)ethoxy]carbamate |
| Molecular Formula | C9H19NO5 |
| Purity | ≥95% |
| InChI | InChI=1S/C9H19NO5/c1-9(2,3)15-8(12)10-14-7-6-13-5-4-11/h11H,4-7H2,1-3H3,(H,10,12) |
| InChIKey | ZPZCGPKXSQMUKY-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NOCCOCCO |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
