Boc-C1-PEG2-C4-Cl

• CAT Number: I019942
• CAS Number: 1835705-53-7
• Molecular Formula: C14H27ClO4
• Molecular Weight: 294.81
• Purity: ≥95%
• Synonyms: tert-butyl 2-[2-(6-chlorohexoxy)ethoxy]acetate
• InChI: InChI=1S/C14H27ClO4/c1-14(2,3)19-13(16)12-18-11-10-17-9-7-5-4-6-8-15/h4-12H2,1-3H3
• InChIKey: GRFAVKLYDZBECC-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)COCCOCCCCCCCl

Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTAC technology employs small molecules that recruit target proteins for ubiquitination and removal by the proteasome. The synthesis of PROTAC compounds that mediate the degradation of c-ABL and BCR-ABL by recruiting either Cereblon or Von Hippel Lindau E3 ligases is reported. Boc-C1-PEG2-C4-Cl is designated as 6-2-2[1].

Reference

[1]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.
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