Boc-C1-PEG3-C4-OH

• CAT Number: I017546
• CAS Number: 2376724-97-7
• Molecular Formula: C16H32O6
• Molecular Weight: 320.42
• Purity: ≥95%
• Synonyms: tert-butyl 2-[2-[2-(6-hydroxyhexoxy)ethoxy]ethoxy]acetate
• InChI: InChI=1S/C16H32O6/c1-16(2,3)22-15(18)14-21-13-12-20-11-10-19-9-7-5-4-6-8-17/h17H,4-14H2,1-3H3
• InChIKey: RFJQECXXHSDFPN-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)COCCOCCOCCCCCCO

Boc-C1-PEG3-C4-OH is a PROTAC linker, which refers to the Alkyl/ether composition. Boc-C1-PEG3-C4-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.
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