Boc-C16-NHS ester

• CAT Number: I016030
• CAS Number: 843666-34-2
• Molecular Formula: C₂₆H₄₅NO₆
• Molecular Weight: 467.64
• Purity: ≥95%
• Target: PROTAC Linkers
• Storage: 2-8°C
• IUPAC Name: 1-O-tert-butyl 18-O-(2,5-dioxopyrrolidin-1-yl) octadecanedioate
• InChI: InChI=1S/C26H45NO6/c1-26(2,3)32-24(30)18-16-14-12-10-8-6-4-5-7-9-11-13-15-17-19-25(31)33-27-22(28)20-21-23(27)29/h4-21H2,1-3H3
• InChIKey: JTOVMMPSILRQQJ-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCC(=O)ON1C(=O)CCC1=O

Boc-C16-NHS ester（Cat No.:I016030） is an alkyl/ether-based linker commonly used in the synthesis of Proteolysis-Targeting Chimeras (PROTACs). It serves as a crucial component for connecting the target protein-ligand and the E3 ligase ligand in a PROTAC molecule. Boc-C16-NHS ester contains a Boc (tert-butyloxycarbonyl) protecting group, which helps enhance stability during synthesis. The linker’s C16 alkyl chain provides hydrophobicity and flexibility to the PROTAC, facilitating effective target engagement and subsequent ubiquitination and degradation of the target protein. Boc-C16-NHS ester plays a vital role in constructing PROTACs, which are emerging as promising therapeutic agents for targeted protein degradation.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562