BOC-D-FMK

• CAT Number: I004394
• CAS Number: 634911-80-1
• Molecular Formula: C11H18FNO5
• Molecular Weight: 263.26
• Purity: ≥95%
• Target: Capase inhibitor
• Solubility: DMSO: ≥ 125 mg/mL
• Storage: Store at -20°C

BOC-D-FMK (CAT: I004394) is a cell-permeable, irreversible caspase inhibitor commonly used in research related to apoptosis and caspase-dependent cell death pathways. It belongs to the class of peptide-based caspase inhibitors. BOC-D-FMK acts by irreversibly binding to the active site of caspases, particularly caspase-1, caspase-3, caspase-6, caspase-7, and caspase-8, inhibiting their enzymatic activity. This inhibition prevents the proteolytic cleavage of caspase substrates and subsequent apoptosis induction. BOC-D-FMK has been employed in various experimental settings to investigate the role of caspases in cellular processes, including apoptosis, inflammation, and immune responses. It serves as a valuable tool for studying caspase-dependent signaling pathways and evaluating the therapeutic potential of caspase inhibition in different disease contexts.

Reference

[1]. Landgraeber S, et al. Pan-caspase inhibition suppresses polyethylene particle-induced osteolysis. Apoptosis. 2009 Feb;14(2):173-81.
[2]. Grigoryan RS, et al. Flow cytometry analysis of single-strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody. Cytometry A. 2007 Nov;71(11):951-60.
[3]. Yee SB, et al. zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells. Exp Mol Med. 2006 Dec 31;38(6):634-42.