Boc-Ile-Glu-Gly-Arg-AMC

For research use only. Not for therapeutic Use.

  • CAT Number: I017680
  • CAS Number: 65147-06-0
  • Molecular Formula: C₃₄H₅₀N₈O₁₀
  • Molecular Weight: 730.81
  • Purity: ≥95%
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Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC)(CAT: I017680) is a fluorogenic peptide substrate specifically designed for the activated Factor X (FXa) enzyme. It features a Boc-protected tetrapeptide sequence (IEGR) linked to 7-amino-4-methylcoumarin (AMC), which releases a fluorescent signal upon cleavage by FXa. This substrate is widely used in coagulation research, particularly for the determination of Factor VIII activity in plasma and other biological samples. Boc-Ile-Glu-Gly-Arg-AMC provides high sensitivity and reproducibility, making it an essential tool for studying coagulation pathways, developing anticoagulant therapies, and evaluating the functionality of blood-clotting factors in various experimental setups.


Catalog Number I017680
CAS Number 65147-06-0
Molecular Formula C₃₄H₅₀N₈O₁₀
Purity ≥95%
Target Factor Xa
IUPAC Name (4S)-5-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-4-[[(2S,3S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoyl]amino]-5-oxopentanoic acid
InChI InChI=1S/C34H50N8O10/c1-7-18(2)28(42-33(50)52-34(4,5)6)31(49)41-23(12-13-26(44)45)29(47)38-17-25(43)40-22(9-8-14-37-32(35)36)30(48)39-20-10-11-21-19(3)15-27(46)51-24(21)16-20/h10-11,15-16,18,22-23,28H,7-9,12-14,17H2,1-6H3,(H,38,47)(H,39,48)(H,40,43)(H,41,49)(H,42,50)(H,44,45)(H4,35,36,37)/t18-,22-,23-,28-/m0/s1
InChIKey YWSYLEUAJLDOJG-SBZQNBARSA-N
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C)NC(=O)OC(C)(C)C

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