Boc-N-PEG1-C2-NHS ester

• CAT Number: I016642
• CAS Number: 1260092-55-4
• Molecular Formula: C₁₄H₂₂N₂O₇
• Molecular Weight: 330.33
• Purity: ≥95%
• Target: PROTAC Linkers

Boc-N-PEG1-C2-NHS ester (CAT: I016642) is a PEG-based PROTAC linker designed for use in the synthesis of PROTAC molecules. With its N-hydroxysuccinimide (NHS) ester functional group, this linker enables efficient coupling of molecules to form bifunctional conjugates. The linker’s Boc-protected amine and PEG moiety contribute to its stability and biocompatibility. This linker is valuable for connecting target-specific ligands or warheads to protein degraders, facilitating the creation of PROTACs—a promising class of compounds for targeted protein degradation in drug discovery and development efforts within the field of chemical biology and therapeutics.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562