For research use only. Not for therapeutic Use.
Boc-N-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I015998 |
| CAS Number | 302331-20-0 |
| Synonyms | 2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethyl methanesulfonate |
| Molecular Formula | C10H21NO6S |
| Purity | ≥95% |
| InChI | InChI=1S/C10H21NO6S/c1-10(2,3)17-9(12)11-5-6-15-7-8-16-18(4,13)14/h5-8H2,1-4H3,(H,11,12) |
| InChIKey | ZDLSZXWATPDDQS-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NCCOCCOS(=O)(=O)C |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
