For research use only. Not for therapeutic Use.
Boc-NH-ethyl-SS-propionic acid(Cat No.:I016122) is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). It consists of a Boc (tert-butyloxycarbonyl) protective group, an NH-ethyl spacer, and an SS-propionic acid moiety. The Boc group provides stability during the conjugation process, while the NH-ethyl spacer offers flexibility and hydrophilicity. The SS-propionic acid linker allows for the selective release of the drug payload within the target cell’s environment, enabling targeted drug delivery and enhancing therapeutic efficacy in ADC-based treatments for cancer and other diseases.
Catalog Number | I016122 |
CAS Number | 485800-27-9 |
Molecular Formula | C₁₀H₁₉NO₄S₂ |
Purity | ≥95% |
Target | ADC Linker |
Storage | Room Temperature |
IUPAC Name | 3-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyldisulfanyl]propanoic acid |
InChI | InChI=1S/C10H19NO4S2/c1-10(2,3)15-9(14)11-5-7-17-16-6-4-8(12)13/h4-7H2,1-3H3,(H,11,14)(H,12,13) |
InChIKey | CIJZYVBXQKYUFA-UHFFFAOYSA-N |
SMILES | CC(C)(C)OC(=O)NCCSSCCC(=O)O |
Reference | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. |