Boc-NH-ethyl-SS-propionic acid

For research use only. Not for therapeutic Use.

  • CAT Number: I016122
  • CAS Number: 485800-27-9
  • Molecular Formula: C₁₀H₁₉NO₄S₂
  • Molecular Weight: 281.39
  • Purity: ≥95%
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Boc-NH-ethyl-SS-propionic acid(Cat No.:I016122) is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). It consists of a Boc (tert-butyloxycarbonyl) protective group, an NH-ethyl spacer, and an SS-propionic acid moiety. The Boc group provides stability during the conjugation process, while the NH-ethyl spacer offers flexibility and hydrophilicity. The SS-propionic acid linker allows for the selective release of the drug payload within the target cell’s environment, enabling targeted drug delivery and enhancing therapeutic efficacy in ADC-based treatments for cancer and other diseases.


Catalog Number I016122
CAS Number 485800-27-9
Molecular Formula C₁₀H₁₉NO₄S₂
Purity ≥95%
Target ADC Linker
Storage Room Temperature
IUPAC Name 3-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyldisulfanyl]propanoic acid
InChI InChI=1S/C10H19NO4S2/c1-10(2,3)15-9(14)11-5-7-17-16-6-4-8(12)13/h4-7H2,1-3H3,(H,11,14)(H,12,13)
InChIKey CIJZYVBXQKYUFA-UHFFFAOYSA-N
SMILES CC(C)(C)OC(=O)NCCSSCCC(=O)O
Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

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