Boc-NH-PEG11-OH

• CAT Number: I016178
• CAS Number: 1556847-53-0
• Molecular Formula: C₂₇H₅₅NO₁₃
• Molecular Weight: 601.72
• Purity: ≥95%
• Target: PROTAC Linkers

Boc-NH-PEG11-OH(CAT: I016178) stands as a valuable component in the realm of targeted protein degradation and PROTAC (PROteolysis TArgeting Chimeras) technology. As a PEG-based PROTAC linker, Boc-NH-PEG11-OH serves as a crucial bridging unit that facilitates the connection between a ligand for a specific protein target and an E3 ligase-recruiting moiety. This linker’s hydrophilic polyethylene glycol (PEG) nature can contribute to solubility and stability while maintaining the required distance between the binding moieties.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.