Boc-NH-PEG2-NH-Boc

• CAT Number: I016595
• CAS Number: 475591-59-4
• Molecular Formula: C16H32N2O6
• Molecular Weight: 348.44
• Purity: ≥95%
• Synonyms: tert-butyl N-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethyl]carbamate
• InChI: InChI=1S/C16H32N2O6/c1-15(2,3)23-13(19)17-7-9-21-11-12-22-10-8-18-14(20)24-16(4,5)6/h7-12H2,1-6H3,(H,17,19)(H,18,20)
• InChIKey: IBOKAWABMPUDFK-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCOCCOCCNC(=O)OC(C)(C)C

Boc-NH-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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