Boc-NH-PEG8-CH2CH2NH2

• CAT Number: I016180
• CAS Number: 1052207-59-6
• Molecular Formula: C₂₃H₄₈N₂O₁₀
• Molecular Weight: 512.63
• Purity: ≥95%
• Target: PROTAC Linkers

Boc-NH-PEG8-CH2CH2NH2(CAT: I016180) serves as a PEG-based linker integral to constructing PROTACs (PROteolysis Targeting Chimeras)[1]. Within the architecture of PROTACs, this linker facilitates the connection of two distinct ligands—one specifically designed for an E3 ubiquitin ligase, and the other tailored for the target protein. This strategic assembly capitalizes on the cellular ubiquitin-proteasome system, orchestrating the targeted degradation of selected proteins[1]. Boc-NH-PEG8-CH2CH2NH2’s role lies in enabling the synthesis of these intricate PROTAC molecules, paving the way for innovative drug development strategies, particularly in the realm of protein degradation-based therapies.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562