Boc-Ser-OtBu

• CAT Number: R028869
• CAS Number: 7738-22-9
• Molecular Formula: C12H23NO5
• Molecular Weight: 261.32
• Purity: ≥95%
• Synonyms: tert-butyl (2S)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
• InChI: InChI=1S/C12H23NO5/c1-11(2,3)17-9(15)8(7-14)13-10(16)18-12(4,5)6/h8,14H,7H2,1-6H3,(H,13,16)/t8-/m0/s1
• InChIKey: NSNZHQVMWJPBPI-QMMMGPOBSA-N
• SMILES: CC(C)(C)OC(=O)[C@H](CO)NC(=O)OC(C)(C)C

Boc-Ser-OtBu（Cat No.:R028869）is a derivative of serine (Ser) where the N-terminal amine is protected by a tert-butoxycarbonyl (Boc) group, and the hydroxyl group of the serine side chain is protected by a tert-butyl (OtBu) group. This modification is commonly used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), to prevent unwanted side reactions at both the amine and hydroxyl groups. The Boc protection allows selective deprotection during peptide chain elongation, while the OtBu group stabilizes the serine residue, making it useful in the synthesis of bioactive peptides and pharmaceuticals.