Boc-Val-Cit-PAB-PNP

• CAT Number: I016634
• CAS Number: 870487-10-8
• Molecular Formula: C₃₀H₄₀N₆O₁₀
• Molecular Weight: 644.67
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
• InChI: InChI=1S/C30H40N6O10/c1-18(2)24(35-28(40)46-30(3,4)5)26(38)34-23(7-6-16-32-27(31)39)25(37)33-20-10-8-19(9-11-20)17-44-29(41)45-22-14-12-21(13-15-22)36(42)43/h8-15,18,23-24H,6-7,16-17H2,1-5H3,(H,33,37)(H,34,38)(H,35,40)(H3,31,32,39)/t23-,24-/m0/s1
• InChIKey: SKWLDDHVHXQPOG-ZEQRLZLVSA-N
• SMILES: CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)OC(C)(C)C

Boc-Val-Cit-PAB-PNP（Cat No.:I016634） is an ADC linker employed in the production of antibody-drug conjugates (ADCs). This linker consists of a Boc protecting group followed by Valine (Val), Citrulline (Cit), p-aminobenzyloxycarbonyl (PAB), and a p-nitrophenyl (PNP) moiety. The Boc group enables stability during synthesis, while the Val and Cit residues contribute to enzymatic cleavage within tumor cells. The PAB-PNP part provides a site for attachment to the antibody and subsequent release of the drug payload upon internalization and cleavage by cellular enzymes.

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.