For research use only. Not for therapeutic Use.
Bocconoline is a potent early endosome antigen 1 (EEA1) inhibitor. Bocconoline can be isolated from Macleaya cordata. Bocconoline can be used for the research of Parkinson’s disease (PD)[1].
Bocconoline (compound 3) (30 μM; 24 h; hONS cells) affects primarily on EEA1 marker intensity in the cytoplasm, mitochondria marker intensity in inner region of the cytoplasm and microtubule-associated protein light chain 3B (LC3b) marker intensity in inner region of cytoplasm[1].
| Catalog Number | I043346 |
| CAS Number | 32906-88-0 |
| Synonyms | (1,2-dimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridin-13-yl)methanol |
| Molecular Formula | C22H21NO5 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H21NO5/c1-23-16(10-24)20-13(6-7-17(25-2)22(20)26-3)14-5-4-12-8-18-19(28-11-27-18)9-15(12)21(14)23/h4-9,16,24H,10-11H2,1-3H3 |
| InChIKey | GKBDCSXIKLSKMH-UHFFFAOYSA-N |
| SMILES | CN1C(C2=C(C=CC(=C2OC)OC)C3=C1C4=CC5=C(C=C4C=C3)OCO5)CO |
| Reference | [1]. Nguyen DT, et al. Chemical constituents from Macleaya cordata (Willd) R. Br. and their phenotypic functions against a Parkinson’s disease patient-derived cell line. Bioorg Med Chem. 2020 Nov 1;28(21):115732. |
