For research use only. Not for therapeutic Use.
Boldine is a naturally occurring alkaloid extracted from the boldo tree (Peumus boldus). It has been extensively studied for its antioxidant, anti-inflammatory, and hepatoprotective properties. Boldine exhibits potent free radical scavenging activity, making it valuable in protecting cells from oxidative stress. Additionally, it has shown promise in supporting liver health by enhancing bile secretion and protecting against liver toxins. Boldine’s pharmacological potential extends to neuroprotection and cardiovascular health, making it a compound of interest in pharmaceutical research and development. Its natural origin and therapeutic benefits highlight its significance in both traditional medicine and modern therapeutic applications.
| Catalog Number | R021528 |
| CAS Number | 476-70-0 |
| Synonyms | (6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol |
| Molecular Formula | C19H21NO4 |
| Purity | ≥95% |
| IUPAC Name | (6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol |
| InChI | InChI=1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1 |
| InChIKey | LZJRNLRASBVRRX-ZDUSSCGKSA-N |
| SMILES | CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=CC(=C(C=C43)OC)O)OC)O |
| Reference | [1]. Zhao H , et al. Boldine isolated from Litsea cubeba inhibits bone resorption by suppressing the osteoclast differentiation in collagen-induced arthritis. Int Immunopharmacol. 2017 Oct;51:114-123. [2]. Gerhardt D, et al. Boldine induces cell cycle arrest and apoptosis in T24 human bladder cancer cell line via regulation of ERK, AKT, and GSK-3β. Urol Oncol. 2014 Jan;32(1):36.e1-9. [3]. Pandurangan AK, et al. Boldine suppresses dextran sulfate sodium-induced mouse experimental colitis: NF-κB and IL-6/STAT3 as potential targets. Biofactors. 2016 May;42(3):247-58. |
