For research use only. Not for therapeutic Use.
Bomedemstat（Cat No.:I023610）, also referred to as IMG-7289, is an inhibitor of lysine-specific histone demethylase 1 (LSD1) with potential antineoplastic activity. It shows promise in the treatment of conditions such as acute myeloid leukemia, myelodysplastic syndrome, and myelofibrosis. Bomedemstat selectively inhibits the proliferation of JAK2 V617F cells, inducing apoptosis. It achieves this by increasing the expression and methylation of p53, along with the pro-apoptotic factor PUMA, while reducing the levels of the antiapoptotic antagonist BCLXL.
| Catalog Number | I023610 |
| CAS Number | 1990504-72-7 |
| Synonyms | IMG-7289 ditosylate; IMG 7289; IMG7289; Bomedemstat ditosylate; |
| Molecular Formula | C42H50FN7O8S2 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | 4°C, away from moisture |
| IUPAC Name | N-[(2S)-5-[[(1R,2S)-2-(4-fluorophenyl)cyclopropyl]amino]-1-(4-methylpiperazin-1-yl)-1-oxopentan-2-yl]-4-(triazol-1-yl)benzamide;4-methylbenzenesulfonic acid |
| InChI | InChI=1S/C28H34FN7O2.2C7H8O3S/c1-34-15-17-35(18-16-34)28(38)25(3-2-12-30-26-19-24(26)20-4-8-22(29)9-5-20)32-27(37)21-6-10-23(11-7-21)36-14-13-31-33-36;2*1-6-2-4-7(5-3-6)11(8,9)10/h4-11,13-14,24-26,30H,2-3,12,15-19H2,1H3,(H,32,37);2*2-5H,1H3,(H,8,9,10)/t24-,25-,26+;;/m0../s1 |
| InChIKey | WLRWBXFBIJMKHG-DVNXTAPYSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCN(CC1)C(=O)[C@H](CCCN[C@@H]2C[C@H]2C3=CC=C(C=C3)F)NC(=O)C4=CC=C(C=C4)N5C=CN=N5 |
| Reference | 1: Fu X, Zhang P, Yu B. Advances toward LSD1 inhibitors for cancer therapy. Future Med Chem. 2017 Jul;9(11):1227-1242. doi: 10.4155/fmc-2017-0068. Epub 2017 Jul 19. Review. PubMed PMID: 28722477. |
