Boromycin

For research use only. Not for therapeutic Use.

  • CAT Number: I023621
  • CAS Number: 34524-20-4
  • Molecular Formula: C45H74BNO15
  • Molecular Weight: 879.89
  • Purity: 98%
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Boromycin(CAT: I023621) is a boron-containing macrolide antibiotic with diverse biological activities. It inhibits the growth of Bacillus subtilis by inducing potassium ion efflux without affecting Na+/K+-ATPase activity and suppresses protein, RNA, and DNA synthesis. It also inhibits Bacillus halodurans by targeting the futalosine pathway in menaquinone synthesis. Beyond its antibacterial properties, Boromycin exhibits antiviral activity, inhibiting replication of HIV-1 and HIV-2 strains in MT-4 cells and peripheral blood mononuclear cells. Additionally, it reverses bleomycin-induced G2 phase cell cycle arrest in Jurkat cells, highlighting its potential in oncology and antiviral research. Its multifunctional mechanism makes it a valuable tool for therapeutic development.


Catalog Number I023621
CAS Number 34524-20-4
Synonyms

Boromycin

Molecular Formula C45H74BNO15
Purity 98%
Target Antibiotic
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name [(2R)-1-[(1R)-1-[(1R,5S,7E,11S,13S,16R,17R,24S,25R,27R,31R,33S,36R)-11,31-dihydroxy-12,12,16,25,32,32,36-heptamethyl-3,22-dioxo-4,18,20,23,26,37,38,40,41-nonaoxa-19-boranuidaheptacyclo[17.17.1.11,33.12,19.113,17.124,27.017,21]hentetracont-7-en-5-yl]ethoxy]-3-methyl-1-oxobutan-2-yl]azanium
InChI InChI=1S/C45H73BNO15/c1-24(2)36(47)39(50)54-27(5)30-16-12-11-13-17-32(48)42(7,8)34-21-19-26(4)45(57-34)38-41(52)56-31-23-29(53-28(31)6)15-14-18-33(49)43(9,10)35-22-20-25(3)44(58-35)37(40(51)55-30)59-46(60-38,61-44)62-45/h11-12,24-38,48-49H,13-23,47H2,1-10H3/q-1/p+1/b12-11+/t25-,26-,27-,28-,29-,30+,31+,32+,33-,34+,35+,36-,37+,38+,44+,45+/m1/s1
InChIKey OOBFYEMEQCZLJL-QAZYKMQESA-O
SMILES [B-]123OC4C(=O)O[C@@H](C/C=C/CC[C@@H](C([C@@H]5CC[C@H]([C@@](O1)(O5)C(O2)C(=O)O[C@H]6C[C@@H](CCC[C@H](C([C@@H]7CC[C@H]([C@@]4(O3)O7)C)(C)C)O)O[C@@H]6C)C)(C)C)O)[C@@H](C)OC(=O)[C@@H](C(C)C)[NH3+]

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