For research use only. Not for therapeutic Use.
Boromycin is a boron-containing macrolide antibiotic that inhibits growth of B. subtilis and induces efflux of potassium ions from B. subtilis without affecting Na+/K+-ATPase activity. It decreases the synthesis of protein, RNA, and DNA in B. subtilis, inhibits the growth of B. halodurans, and inhibits the futalosine pathway of menaquinone synthesis in B. halodurans. Boromycin reverses bleomycin-induced cell cycle arrest at the G2 phase in Jurkat cells. It inhibits replication of the HIV-1 strains LAV-1 and RF and the HIV-2 strain LAV-2 in MT-4 cells. It also inhibits replication of a clinical isolate of HIV-1, strain KK-1, in MT-4 cells and peripheral blood mononuclear cells.
| Catalog Number | I023621 |
| CAS Number | 34524-20-4 |
| Synonyms | Boromycin |
| Molecular Formula | C45H74BNO15 |
| Purity | 98% |
| Target | Antibiotic |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (T-4)-[(1R)-1-[(1S,2R,5S,6R,8R,12R,14S,17R,18S,19R,22S,24Z,28S,30S,33R)-1,2,18,19-tetra(hydroxy-κO)-12,28-dihydroxy-6,13,13,17,29,29,33-heptamethyl-3,20-dioxo-4,7,21,34,35-pentaoxatetracyclo[28.3.1.15,8.114,18]hexatriacont-24-en-22-yl]ethyl D-valinato(4-)]-borate(1-), monohydrogen |
| InChI | InChI=1S/C45H73BNO15/c1-24(2)36(47)39(50)54-27(5)30-16-12-11-13-17-32(48)42(7,8)34-21-19-26(4)45(57-34)38-41(52)56-31-23-29(53-28(31)6)15-14-18-33(49)43(9,10)35-22-20-25(3)44(58-35)37(40(51)55-30)59-46(60-38,61-44)62-45/h11-12,24-38,48-49H,13-23,47H2,1-10H3/q-1/p+1/b12-11+/t25-,26-,27-,28-,29-,30+,31+,32+,33-,34+,35+,36-,37+,38+,44+,45+/m1/s1 |
| InChIKey | OOBFYEMEQCZLJL-QAZYKMQESA-O |
| SMILES | C[C@H](CC[C@@H](C(C)([C@H](CC/C=C/C[C@@H]([C@@H](C)OC([C@H](N)C(C)C)=O)O1)O)C)O2)[C@]32[O-][B+3]4([O-][C@]5(O[C@H](C6(C)C)CC[C@H]5C)[C@H](C1=O)[O-]4)[O-][C@H]3C(O[C@H]7C[C@@H](CCC[C@H]6O)O[C@@H]7C)=O.[H+] |
| Reference | 1. Kohno, J., Kawahata, T., Otake, T., et al. Boromycin, an anti-HIV antibiotic. Biosci. Biotech. Biochem. 60(6), 1036-1037 (1996). |
