For research use only. Not for therapeutic Use.
Borrelidin（Cat No.:R027584）is a naturally occurring compound with potent antimicrobial and anti-inflammatory properties, primarily derived from the bacterium Streptomyces species. It acts as a selective inhibitor of protein synthesis, disrupting the function of various bacterial and fungal pathogens. Its unique mechanism of action makes Borrelidin a valuable lead compound in drug discovery, particularly in developing new antibiotics and antifungal agents. Ongoing research is focused on its potential therapeutic applications in treating resistant infections and its use in combination therapies to enhance efficacy against challenging microbial strains.
| Catalog Number | R027584 |
| CAS Number | 7184-60-3 |
| Synonyms | (1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]-Cyclopentanecarboxylic Acid; [2S-[2R*(1S*,2S*),4E,6Z,8S*,9R*,11S*,13R*,15R*,16R*]]-2-(7-Cyano-8,16-dihydroxy-9,11,13,15-te |
| Molecular Formula | C₂₈H₄₃NO₆ |
| Purity | 99% |
| Target | Synthases/Synthetases |
| Solubility | Limited solubility |
| Appearance | White Lyophilisate |
| Storage | Store at -20C |
| Analysis method | HPLC |
| IUPAC Name | (1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid |
| InChI | InChI=1S/C28H43NO6/c1-17-12-18(2)14-20(4)27(32)21(16-29)8-5-6-11-25(22-9-7-10-23(22)28(33)34)35-26(31)15-24(30)19(3)13-17/h5-6,8,17-20,22-25,27,30,32H,7,9-15H2,1-4H3,(H,33,34)/b6-5+,21-8-/t17-,18+,19-,20-,22+,23+,24-,25-,27+/m0/s1 |
| InChIKey | OJCKRNPLOZHAOU-UGKRXNSESA-N |
| SMILES | C[C@H]1C[C@H](C[C@@H]([C@H](/C(=C\C=C\C[C@H](OC(=O)C[C@@H]([C@H](C1)C)O)[C@@H]2CCC[C@H]2C(=O)O)/C#N)O)C)C |
| Reference | A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases. Ruan T. et al. , J. Biol. Chem. 2005, 280, 571. <br /> |
