For research use only. Not for therapeutic Use.
Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with K<sub>i</sub> of 4.7 nM and 95 nM, respectively.<br>Bosentan competitively antagonizes the specific binding of [<br>Bosentan inhibits the presser response to big ET-1 both after i.v. and oral administration, with a long duration of action and no intrinsic agonist activity. Bosentan also inhibits the depressor and presser effect of ET-1 and sarafotoxin S6C. Its pharmacological profile makes Bosentan a potentially useful drug in the management of clinical disorders associated with vasoconstriction.
| Catalog Number | A000455 |
| CAS Number | 157212-55-0 |
| Synonyms | Ro 47-0203 |
| Molecular Formula | C27H31N5O7S |
| Purity | ≥95% |
| Target | Endothelin Receptor |
| Solubility | >28.5mg/mL in DMSO |
| Storage | 3 years -20C powder |
