For research use only. Not for therapeutic Use.
Bosutinib hydrate（Cat No.:I043488）is a potent tyrosine kinase inhibitor used in the treatment of chronic myelogenous leukemia (CML), particularly in patients with resistance or intolerance to other therapies. It works by inhibiting the BCR-ABL fusion protein, which is responsible for the uncontrolled growth of leukemic cells. Bosutinib targets multiple kinase pathways involved in cancer cell proliferation, including SRC family kinases. As a second-line therapy, it has shown efficacy in controlling disease progression and improving patient outcomes. The hydrate form ensures stability and bioavailability of the compound during treatment.
| CAS Number | 918639-08-4 |
| Synonyms | 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile;hydrate |
| Molecular Formula | C26H31Cl2N5O4 |
| Purity | ≥95% |
| IUPAC Name | 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile;hydrate |
| InChI | InChI=1S/C26H29Cl2N5O3.H2O/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27;/h11-14,16H,4-10H2,1-3H3,(H,30,31);1H2 |
| InChIKey | BXPOSPOKHGNMEP-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC.O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
