Bosutinib (SKI-606)

• CAT Number: A000261
• CAS Number: 380843-75-4
• Molecular Formula: C₂₆H₂₉Cl₂N₅O₃
• Molecular Weight: 530.45
• Purity: ≥95%
• Target: Bcr-Abl
• Solubility: >26.5mg/mL in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
• InChI: InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)
• InChIKey: UBPYILGKFZZVDX-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC

Bosutinib (SKI-606)（Cat No.:A000261）is a potent tyrosine kinase inhibitor that primarily targets BCR-ABL and Src family kinases, making it an effective treatment for chronic myeloid leukemia (CML) with resistance or intolerance to prior therapies. By inhibiting these kinases, bosutinib disrupts cancer cell signaling pathways involved in proliferation and survival, particularly in CML cells with the Philadelphia chromosome mutation. Bosutinib also has activity against Src kinases, offering potential in targeting solid tumors. Its ability to overcome resistance makes it a valuable option in managing CML and other malignancies.

Reference

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