BPAM-344

• CAT Number: I023632
• CAS Number: 1204572-55-3
• Molecular Formula: C10H11FN2O2S
• Molecular Weight: 242.2684
• Purity: 98%
• Synonyms: BPAM-344; BPAM344; BPAM 344
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
• InChI: InChI=1S/C10H11FN2O2S/c11-7-1-4-9-10(5-7)16(14,15)12-6-13(9)8-2-3-8/h1,4-5,8,12H,2-3,6H2
• InChIKey: FLTMTBPCYAZIKM-UHFFFAOYSA-N
• SMILES: FC1=CC=C(C2=C1)N(C3CC3)CNS2(=O)=O

BPAM-344 is a Positive Allosteric Modulator of Kainate Receptor. BPAM344 potentiated glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreased desensitization kinetics (from 5.5 to 775 ms).

Reference

1: Larsen AP, Fièvre S, Frydenvang K, Francotte P, Pirotte B, Kastrup JS, Mulle C. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol Pharmacol. 2017 Jun;91(6):576-585. doi: 10.1124/mol.116.107599. Epub 2017 Mar 30. PMID: 28360094.
2: Krintel C, Francotte P, Pickering DS, Juknaitė L, Pøhlsgaard J, Olsen L, Frydenvang K, Goffin E, Pirotte B, Kastrup JS. Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. Biophys J. 2016 Jun 7;110(11):2397-2406. doi: 10.1016/j.bpj.2016.04.032. PMID: 27276258; PMCID: PMC4906162.