BPAM-344

• CAT Number: I023632
• CAS Number: 1204572-55-3
• Molecular Formula: C10H11FN2O2S
• Molecular Weight: 242.27
• Purity: 98%
• Synonyms: BPAM-344; BPAM344; BPAM 344
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4-cyclopropyl-7-fluoro-2,3-dihydro-1lambda6,2,4-benzothiadiazine 1,1-dioxide
• InChI: InChI=1S/C10H11FN2O2S/c11-7-1-4-9-10(5-7)16(14,15)12-6-13(9)8-2-3-8/h1,4-5,8,12H,2-3,6H2
• InChIKey: FLTMTBPCYAZIKM-UHFFFAOYSA-N
• SMILES: FC1=CC=C(C2=C1)N(C3CC3)CNS2(=O)=O

BPAM-344(CAT: I023632) is a potent positive allosteric modulator of kainate receptors, specifically enhancing the activity of GluK2a subunits. It significantly potentiates glutamate-evoked currents, with a 21-fold increase at a concentration of 200 μM and an EC₅₀ of 79 μM. BPAM-344 also markedly reduces desensitization kinetics, extending them from 5.5 ms to 775 ms, thereby stabilizing receptor activation. This compound is a valuable tool for studying kainate receptor function, synaptic plasticity, and excitatory neurotransmission. Its ability to modulate receptor dynamics highlights its potential for therapeutic research in neurological conditions involving kainate receptor dysfunction, such as epilepsy and neurodegenerative diseases.