For research use only. Not for therapeutic Use.
BPDBA is a selective and noncompetitive betaine/GABA transporter (BGT-1) inhibitor with IC50s of 20 μM and 35 μM against human BGT-1 and mouse GAT2, respectively[1].
BPDBA is predicted to have excellent oral absorption and blood brain barrier penetration properties[1].
| Catalog Number | I023635 |
| CAS Number | 312281-74-6 |
| Synonyms | N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide |
| Molecular Formula | C19H20Cl2N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C19H20Cl2N2O/c20-15-6-7-17(18(21)12-15)19(24)22-16-8-10-23(11-9-16)13-14-4-2-1-3-5-14/h1-7,12,16H,8-11,13H2,(H,22,24) |
| InChIKey | OIDACLQVAGIDMT-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=CC=C3 |
| Reference | [1]. Kragholm B, et al. Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile. Biochem Pharmacol. 2013 Aug 15;86(4):521-8. |
