BPH-715

• CAT Number: I004881
• CAS Number: 1059677-23-4
• Molecular Formula: C17H31NO7P2
• Molecular Weight: 423.38
• Purity: ≥95%
• Synonyms: BPH-715; BPH 715; BPH715; GTPL3196; GTPL 3196; GTPL-3196; Bisphpshonate-715.;hydrogen (2-(3-(decyloxy)pyridin-1-ium-1-yl)-1-phosphonoethyl)phosphonate
• Target: Parasite
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term or -20 °C for long term
• IUPAC Name: [2-(3-decoxypyridin-1-ium-1-yl)-1-phosphonoethyl]-hydroxyphosphinate
• InChI: InChI=1S/C17H31NO7P2/c1-2-3-4-5-6-7-8-9-13-25-16-11-10-12-18(14-16)15-17(26(19,20)21)27(22,23)24/h10-12,14,17H,2-9,13,15H2,1H3,(H3-,19,20,21,22,23,24)
• InChIKey: QYJHUOZDBUEKQC-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCOC1=C[N+](=CC=C1)CC(P(=O)(O)O)P(=O)(O)[O-]

BPH-715（Cat No.:I004881）is a bisphosphonate compound that inhibits the liver-stage growth of Plasmodium species, the parasites responsible for malaria. In HepG2 cell studies, it has demonstrated an IC₅₀ of 10 μM against Plasmodium exoerythrocytic forms, indicating its potential as an antimalarial agent.By targeting the parasite’s development in the liver, BPH-715 offers a strategic approach to malaria treatment, aiming to prevent the disease’s progression to symptomatic blood stages. Its efficacy in preclinical models positions it as a promising candidate for further research in malaria therapeutics.

Reference

1: Singh AP, Zhang Y, No JH, Docampo R, Nussenzweig V, Oldfield E. Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth. Antimicrob Agents Chemother. 2010 Jul;54(7):2987-93. doi: 10.1128/AA