For research use only. Not for therapeutic Use.
BPN-15477 is a potent SMC (splicing modulator compound) that restores correct splicing of ELP1 (Elongator complex protein 1) exon 20. BPN-15477 corrects splicing of the ELP1 transcript, significantly increases the level of functional protein in vivo in all tissues, including brain. BPN-15477 can be used for frontotemporal dementia research[1].
| Catalog Number | I043516 |
| CAS Number | 1971086-99-3 |
| Synonyms | 2-chloro-N-(pyridin-4-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Molecular Formula | C12H10ClN5 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H10ClN5/c13-12-17-10-9(3-6-15-10)11(18-12)16-7-8-1-4-14-5-2-8/h1-6H,7H2,(H2,15,16,17,18) |
| InChIKey | JAAXPOGNLKNTBW-UHFFFAOYSA-N |
| SMILES | C1=CNC2=C1C(=NC(=N2)Cl)NCC3=CC=NC=C3 |
| Reference | [1]. Gao D, et al. A deep learning approach to identify gene targets of a therapeutic for human splicing disorders. Nat Commun. 2021 Jun 7;12(1):3332. |
