For research use only. Not for therapeutic Use.
BPO-27 racemate (Cat.No:I013692) is a potent CFTR inhibitor with an IC50 of 8 nM. Inquire BPO-27 racemate online by filling out the inquiry form, we will get back to you within 24 hours!
| Catalog Number | I013692 |
| CAS Number | 1314873-02-3 |
| Molecular Formula | C₂₆H₁₈BrN₃O₆ |
| Purity | ≥95% |
| Target | CFTR |
| Solubility | DMSO: 6 mg/mL |
| IUPAC Name | 9-(5-bromofuran-2-yl)-12,14-dimethyl-13,15-dioxo-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-2(7),3,5,10,16-pentaene-4-carboxylic acid |
| InChI | InChI=1S/C26H18BrN3O6/c1-28-21-19(24(31)29(2)26(28)34)20(13-6-4-3-5-7-13)30-15-12-14(25(32)33)8-9-16(15)36-23(22(21)30)17-10-11-18(27)35-17/h3-12,23H,1-2H3,(H,32,33) |
| InChIKey | GNHIGSRGYXEQEP-UHFFFAOYSA-N |
| SMILES | CN1C2=C3C(OC4=C(N3C(=C2C(=O)N(C1=O)C)C5=CC=CC=C5)C=C(C=C4)C(=O)O)C6=CC=C(O6)Br |
| Reference | [1]. Snyder DS, et al. Absolute Configuration And Biological Properties of Enantiomers of CFTR Inhibitor BPO-27. ACS Med Chem Lett. 2013 May 9;4(5):456-459.<br>[2]. Kim Y, et al. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct;88(4):689-96. |
